Acute, but Not in Chronic, Multiple Sclerosis Monocytes/Macrophages and/or Astrocytes in Nitrotyrosine Are Found in Inducible Nitric Oxide Synthase
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Inducible nitric oxide synthase and nitrotyrosine are found in monocytes/macrophages and/or astrocytes in acute, but not in chronic, multiple sclerosis.
We have examined the localization of inducible nitric oxide synthase (iNOS) and nitrotyrosine (the product of nitration of tyrosine by peroxynitrite, a highly reactive derivative of nitric oxide [NO]) in demyelinating lesions from (i) two young adult patients with acute multiple sclerosis (MS), (ii) a child with MS (consistent with diffuse sclerosis), and (iii) five adult patients with chronic ...
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تاریخ انتشار 1998